Projectes de recerca competitius finançats per entitats externes
A comprehensive CAD system based on radiologic- and pathologic-image biomarkers for diagnosis and prognosis of breast cancer relapse
Acrònim
BosomShield
Títol projecte
A comprehensive CAD system based on radiologic- and pathologic-image biomarkers for diagnosis and prognosis of breast cancer relapse
Referència externa
101073222
Descripció/abstract
Breast cancer (BC) incidence in women produces more than 600,000 deaths each year. The primary cause of death in BC patients is
metastasis, whereby cancer cells spread from their primary site of origin and grow in adjacent or distant sites. Distant metastasis
produced due to the relapse of the illness is incurable, underscoring the inadequacy of our understanding of its mechanisms. The first
step for fighting against disease progression is screening programs for BC focused on image analysis of mammography, MRI and
tomosynthesis. Once the tumour has been diagnosed and given the high variability of clinical progressions, another problem arises:
classifying the cancer type and determining the proper treatment for specific cancer. Moreover, in BC, the immune response from the
tumour microenvironment has played an essential role in tumour evolution. To evaluate the tumour and its microenvironment, one
technique garnered a lot of attention in the last years: Whole Slide Imaging (WSI). This technique replaces the use of the microscope
for classical diagnosis. Still, it has also been used for developing biomarkers that allow the analysis of tumours and classification of
cancer subtypes and the study of the immune tumour microenvironment. The use of WSI has applications for predicting the
probability of relapse for distant metastasis. Now, for the first time, BosomShield proposes to join the two disciplines (pathological
and radiological imaging) in a software that will analyze these images to classify the cancer subtypes and predict (together with the
complete clinical history of the patient) the probability of relapse for distant metastasis. Besides, BosomShield will provide high-level
training in BC research to young researchers by offering the necessary transferable skills for thriving careers underpinned using
diverse disciplines, digital radiology and pathology, biomedical, AI, privacy and software development.
